Publications
Publication Information
Title | Evaluation of Preoperative and Intraoperative Mobile Gamma Camera Imaging in Sentinel Lymph Node Biopsy for Melanoma Independent of Lymphoscintigraphy |
Authors | Joshua Judge, Kosta Popovic, Gina Petroni, Brian Kross, John McKisson, John McKisson, Andrew Weisenberger, Alexander Stolin, Stan Majewski, Patrice Rehm, Craig Slingluff Jr., Mark Williams, Lynn Dengel |
JLAB number | JLAB-PHY-21-3366 |
LANL number | (None) |
Other number | DOE/OR/23177-5189 |
Document Type(s) | (Journal Article) |
Associated with EIC: | No |
Supported by Jefferson Lab LDRD Funding: | No |
Funding Source: | Nuclear Physics (NP) |
Journal Compiled for Journal of Surgical Research Volume 285 Page(s) 176-186 | |
Publication Abstract: | Background and Objectives: Sentinel lymph node biopsy (SLNB) is standard practice for staging cutaneous melanoma. High false negative rates have increased interest in adjunctive techniques for localizing SLNs. Mobile gamma cameras (MGCs) represent potential tools to enhance SLNB performance. Methods: Twenty eligible melanoma patients underwent 99mTc sulfur colloid injection and standard lymphoscintigraphy with a fixed gamma camera (FGC). A survey using a 20 cm square MGC, performed immediately preoperatively by the study surgeon, was used to establish an operative plan while blinded to the FGC results. Subsequently, SLNB was performed using a gamma probe and a novel 6 cm diameter handheld MGC. Results: A total of 24 SLN basins were detected by FGC. Prior to unblinding, all 24 basins were identified with the preoperative MGC, and the operative plan established by preoperative MGC imaging was confirmed accurate by review of the FGC images. All individual SLNs were identified during intraoperative MGC imaging, and in 5/24 (21%) cases, additional clinical information was obtained from the MGC. Conclusions: Preoperative MGC images provide information consistent with FGC images for planning SLNB and in some cases provides additional information that aided in surgical decision-making. |
Experiment Numbers: | other |
Group: | Detector |
Document: | |
DOI: | https://doi.org/10.1016/j.jss.2022.12.013 |
Accepted Manuscript: | |
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